Methods of Using Acyl-Coenzymea-Binding Proteins to Enhance Tolerance to Necrotrophic Fungal Pathogens in Genetically Modified Plants
- Transgenic Plants and Agriculture
Key Problem and Market Opportunity
- Fungal plant diseases are a significant concern in agriculture and food production worldwide.
- Necrotrophic soil-borne pathogenic fungi such as Rhizoctonia and Fusarium infect major economically-important crops leading to severe yield loss.
- World agriculture sustains average losses of around 16% annually as a result of fungal diseases.
- To ensure a steady and uniform food supply to the rapidly mounting global population, there is an urgent need to control necrotrophic fungal diseases.
- To this end, proteins that can protect plants from necrotrophic phytopathogens must be identified and subsequently tested for efficacy in transgenic crops.
Key Advantages of the Technology
- Acyl-CoA-binding protein (ACBP) are important house-keeping protein family that extends across eukaryotes and some prokaryotes.
- Oryza sativa ACBP (OsACBP5) in plants improves tolerance to fungal necrotrophs
- The present invention describes vectors/expression cassettes for conferring tolerance to fungal necrotrophs along with methods of using OsACBP5 to enhance tolerance to fungal necrotrophs and for screening for genes with OsACBP5-like activity.
- The invention further describes plants and plant material with improved tolerance to fungal necrotrophs.
Potential Product and Services
- Transgenic plants and plant material
- Plant transformation vectors for improving tolerance to fungal necrotrophs in plants
Development Status and IP Strength
- PCT application No. WO2018010075